Troponin
Labtests will measure cardiac Troponin levels using the Siemens Centaur Troponin I (c-Tnl) assay. This assay has a diagnostic cut-off of 0.04 ug/L (compared to diagnostic cut-off for troponin T of 0.03 ug/L as used by DML). Values above 0.04 ug/L in the c-Tnl test are indicative of myocardial injury.
Higher values are generally associated with increased severity of injury (although this may not always follow):
● C-Tnl levels become elevated within 2 to 3 hours after the onset of symptoms, peak at 18-24 hours, and remain elevated for up to 14 days.
● A negative result for c-Tnl should be repeated in 6-12 hours post the onset of chest pain if AMI is suspected. Clearly, where AMI is indicated on clinical grounds or form evidence of ECG changes, requestors should not wait for a troponin result before arranging urgent referral.
● At low detectable concentrations, a rise in consecutive c-Tnl values should be sought before diagnosing acute myocardial infarction. C-Tnl levels following myocardial infraction are generally 5-50 times the cut-off level.
● An elevated c-Tnl level in the setting of clinical ischemia is diagnostic of myocardial damage and need not be repeated.
● A full interpretive comment (with diagnostic cut-off) is supplied on all reports.
PSA
Labtests will measure PSA using the Siemens Centaur PSA assay and report the same age-related cut-off values for PSA as used by the other Auckland diagnostic pathology laboratories. As a rule of thumb, our reported PSA values will be similar to those reported by DML. Labtests is undertaking work to establish the nature of any difference.
INR
The INR (International Normalised Ratio) is effectively a means of standardizing a patient’s prothrombin ratio and is calculated by dividing the patient’s prothrombin time (in seconds) by the mean normal prothrombin time (MNPT) to the power of the ISI. The purpose of this standardization is to allow direct comparison of a patient’s results between laboratories using different testing methods.
Labtests INR results may differ slightly to those reported by DML. Labtests will utilize a different testing platform but use the same reagent as is currently used by DML. While this change is in part catered for by applying a differing ISI value to our INR calculation, there may be small differences in results. Any difference in INR results between Labtests and the current provider are unlikely to require a change in warfarin dosage.